房建凯，现任苏州大学转化医学研究院副教授、硕士生导师，受聘全国高校区域技术转移转化中心生物医药姑苏分中心首批技术经理人。2013年6月于苏州大学护理学院取得护理学本科医学学位；2016年6月于苏州大学基础医学院取得病理学与病理生理学硕士医学学位，并荣获苏州大学“优秀毕业研究生”称号；2020年6月于苏州大学转化医学研究院取得病理学与病理生理学博士医学学位，并荣获苏州大学“优秀毕业研究生”称号；2020年7月留院师从时玉舫院士从事博士后研究，并于2023年8月荣获“优秀”出站考评等第。2023年9月起留任苏州大学转化医学研究院副教授。先后主持国家自然科学基金面上项目1项和国家自然科学基金青年基金1项，参与国家重点研发计划课题2项和江苏省基础研究计划重点项目1项。
邮箱：jkfang@suda.edu.cn
研究方向：
探索炎症微环境中干细胞对重大疾病（自身免疫性疾病、纤维化和肿瘤等）发生发展的调控作用及干预策略。主要研究方向：（1）疾病演进过程中内源性原位干细胞群体和外源性移植干细胞群体受炎症微环境调控的异同点；（2）炎症微环境中调控干细胞参与免疫调节和组织修复的关键免疫细胞和炎症因子；（3）受炎症微环境调控的干细胞其代谢状态的改变在决定自身免疫调节功能和组织修复能力中的作用和机制。
承担国家级项目：
1. 国家自然科学基金委员会，面上项目，82570095，NAD+调控肺MSCs免疫功能演变参与肺纤维化进程的糖脂代谢机制与干预策略，49万元，2026-01至2029-12，主持
2. 国家自然科学基金委员会，青年科学基金项目（C类），82202032，NAD+代谢编程间充质干细胞免疫调控功能的作用机制与优化策略研究，30万元，2023-01至2025-12，主持
研究论文：（#共同第一作者，*通讯作者）
1. Yuzhu Shi#; Jia Zhang#; Yanan Li; Chao Feng; Changshun Shao*; Yufang Shi*; Jiankai Fang*; Engineered mesenchymal stem/stromal cells against cancer, Cell Death & Disease, 2025, 16(1): 113.
2. Weijia Zhang#; Haoyu Ren#; Wangwang Chen#; Bo Hu; Chao Feng; Peishan Li*; Yufang Shi*; Jiankai Fang*; Nicotinamide Phosphoribosyltransferase in NAD+ Metabolism: Physiological and Pathophysiological Implications, Cell Death Discovery, 2025, 11(1): 371.
3. Tingting Wang#; Yanan Li#; Jinyi Tian; Guofu Sun; Tingting Yang; Zhenzhen Meng; Wen Li; Xiao Su; Rui Liu; Pixia Gong; Lijuan Cao; Chao Feng; Dongyan Zhao; Peishan Li; Yufang Shi*; Jiankai Fang*; Changshun Shao*; PARP inhibition augments immunomodulatory function of mesenchymal stem/stromal cells by promoting STAT1 phosphorylation, Stem Cell Research & Therapy, 2025, 16(1):548.
4. Xin Wang; Lijuan Cao; Shisong Liu; Yipeng Zhou; Jiarui Zhou; Wenxuan Zhao; Shengqi Gao; Rui Liu; Yufang Shi; Changshun Shao*; Jiankai Fang*; The critical roles of IGFs in immune modulation and inflammation, Cytokine, 2024, 183: 156750.
5. Shisong Liu#; Pengbo Hou#; Weijia Zhang; Muqiu Zuo; Zhanhong Liu; Tingting Wang; Yipeng Zhou; Wangwang Chen; Chao Feng; Bo Hu*; Jiankai Fang*; Species variations in muscle stem cellmediated immunosuppression on T cells, Scientific Reports, 2024, 14(1): 23410.
6. Jiankai Fang; Pengbo Hou; Shisong Liu; Muqiu Zuo; Zhanhong Liu; Wangwang Chen; Yuyi Han; Yanan Li; Tingting Wang; Chao Feng; Peishan Li; Changshun Shao*; Yufang Shi*; NAD+ salvage governs the immunosuppressive capacity of mesenchymal stem cells, Cellular & Molecular Immunology, 2023, 20(10): 1171-1185.
7. Jiankai Fang#; Wangwang Chen#; Pengbo Hou; Zhanhong Liu; Muqiu Zuo; Shisong Liu; Chao Feng; Yuyi Han; Peishan Li*; Yufang Shi*; Changshun Shao*; NAD+ metabolism-based immunoregulation and therapeutic potential, Cell & Bioscience, 2023, 13(1): 81.
8. Jiankai Fang#; Chao Feng#; Wangwang Chen; Pengbo Hou; Zhanhong Liu; Muqiu Zuo; Yuyi Han; Chenchang Xu; Gerry Melino; Alexei Verkhratsky; Ying Wang; Changshun Shao*; Yufang Shi*; Redressing the interactions between stem cells and immune system in tissue regeneration, Biology Direct, 2021, 16(1): 18.
9. Jiankai Fang#; Shengchao Zhang#; Zhanhong Liu; Yongsha Pan; Lijuan Cao; Pengbo Hou; Yongjing Chen; Yuyan Zhang; Xiaolei Li; Rui Liu; Qianwen Shang; Zhiyuan Zheng; Lin Song; Yanan Li; Zhonglin Fu; Liangyu Lin; Gerry Melino; Ying Wang; Changshun Shao*; Yufang Shi*; Skeletal muscle stem cells confer maturing macrophages anti-inflammatory properties through insulin-like growth factor-2, Stem Cells Translational Medicine, 2020, 9(7): 773-785.
10. Jiankai Fang#; Liang Chen#; Xueguan Lu; Dan Cao; Lingling Guo; Yongsheng Zhang; Liubing Li; Lifeng Zhang; Yuting Kuang*; Shouli Wang*; Optimization of transforming growth factor-beta 1 siRNA loaded chitosan-tripolyphosphate nanoparticles for the treatment of colorectal cancer hepatic metastasis in a mouse model, Journal of Biomedical Nanotechnology, 2016, 12(7): 1489-1500.
11. Muqiu Zuo#; Jiankai Fang#; Peiqing Huang; Shisong Liu; Pengbo Hou; Shiqing Wang; Zhanhong Liu; Chao Feng; Lijuan Cao; Peishan Li; Yufang Shi*; Changshun Shao*; IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells, Cell Death Discovery, 2023, 9(1): 269.
12. Shengchao Zhang#; Jiankai Fang#; Zhanhong Liu; Pengbo Hou; Lijuan Cao; Yuyan Zhang; Rui Liu; Yanan Li; Qianwen Shang; Yongjing Chen; Chao Feng; Guan Wang; Gerry Melino; Ying Wang; Changshun Shao*; Yufang Shi*; Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis, Stem Cell Research & Therapy, 2021, 12(1): 50.
13. Ying Wang; Jiankai Fang; Benming Liu; Changshun Shao; Yufang Shi*; Reciprocal regulation of mesenchymal stem cells and immune responses, Cell Stem Cell, 2022, 29(11): 1515-1530.
授权发明专利：
1. Yufang Shi; Lijuan Cao; Jiankai Fang; Yongjing Chen; Ying Wang; STEM CELL DRUG FOR TREATING DIABETES, 2021-11-4, WIPO, PCT/CN2021/088209
2. 时玉舫；房建凯；邵常顺；陈永井；一种治疗炎症性肠病的细胞药物，2024-8-16，中国，ZL202211191525.9
3. 时玉舫；房建凯；陈永井；张胜超；邵常顺；肌肉干细胞在制备抗炎药物中的应用，2021-7-27，中国，ZL201911358302.5
学术奖励：
房建凯；时玉舫；邵常顺；2022~2023年度苏州市自然科学优秀学术论文一等奖，苏州市人民政府，市厅级