时玉舫，欧洲科学院(Ordinary Member, Academia Europaea)正式院士，苏州大学转化医学研究院院长，中国科学院上海营养与健康研究所客座研究员，罗马第二大学杰出教授、荣誉博士，首批国家特聘专家，国家自然基金委杰出青年；国家973重大研究计划首席科学家；国家重点研发计划首席科学家；国际细胞治疗学会（International Society of Cell Therapy, ISCT）MSC分会专家总体常委；2001年至2008年担任新泽西医科大学终身正教授和特聘大学讲席教授(University Professor)；2008年至2014年担任中国科学院健康科学研究所所长。时玉舫院士长期从事免疫与干细胞研究，在探索免疫稳态维持和组织再生修复的细胞与分子机制等方面取得了一系列原创性、突破性和引领性成果。目前担任Cell Death & Disease杂志主编（Editor-in-Chief）；Oncogene副主编（Associate Editor）；Cell Death & Differentiation编审(Receiving Editor)；Stem Cell Research & Therapy副主编；Cell & BioSciences副主编；Advanced Science副主编（Executive Board）等。在Nature(1989, 1999)，Science(1992)，Nature Medicine(2006, 2012, 2013)，Nature Immunology(2011, 2014, 2024)，Cell Stem Cell(2008, 2012, 2012,2012, 2013, 2019, 2022)，Cell Metabolism(2019)，Immunity (2006, 2011, 2014,2015)，Nature Reviews Drug Discovery(2017)，Nature Reviews Nephrology (2018)，Nature Communications(2017, 2018, 2019, 2021)，PNAS(2007, 2015, 2020, 2023)等国际知名学术期刊发表SCI收录的研究论文350余篇，所发表文章的他引62,000余次，h-index 105；申请专利30余项，授权国际国内专利15项；连续多年被列为全球高被引用学者和顶尖科学家，并先后获得中国侨界贡献奖创新人才奖、山东农业大学杰出校友、中国细胞学会干细胞转化成就奖等。
邮箱：shiyufang2@gmail.com
研究方向：干细胞与免疫调控、干细胞与炎症微环境、免疫治疗
代表性研究论文：（*通讯作者）
1. Jiang X, Wang J, Lin L, Du L, Ding Y, Zheng F, Xie H, Wang Y, Hu M, Liu B, Xu M, Zhai J, Wang X, Ye J, Cao W, Feng C, Feng J, Hou Z, Meng M, Qiu J, Li Q*, Shi Y*, Wang Y*. Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity. Signal Transduct Target Ther. 2024 Dec 18;9(1):352.
2. Zhang J, Shi Y, Xue X, Bu W, Li Y, Yang T, Cao L, Fang J, Li P, Chen Y, Li Z, Shao C*, Shi Y*. Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracranial cancers. Cell Mol Immunol. 2024 Oct;21(10):1145-1157.
3. Shi Y*, Strasser A, Green DR, Latz E, Mantovani A, Melino G*. Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies. Cell Mol Immunol. 2024 Jul;21(7):790-797.
4. Bu W, Sun X, Xue X, Geng S, Yang T, Zhang J, Li Y, Feng C, Liu Q, Zhang X, Li P, Liu Z, Shi Y, Shao C*. Early onset of pathological polyploidization and cellular senescence in hepatocytes lacking RAD51 creates a pro-fibrotic and pro-tumorigenic inflammatory microenvironment. Hepatology. 2025 Feb 1;81(2):491-508.
5. Lin L, Hu M, Li Q, Du L, Lin L, Xue Y, Zheng F, Wang F, Liu K, Wang Y, Ye J, Jiang X, Wang X, Wang J, Zhai J, Liu B, Xie H, You Y, Wang J, Kong X, Feng D, Green DR, Shi Y*, Wang Y*. Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation. Nat Immunol. 2024 Jan;25(1):54-65.
6. Li Q, Lin L, Shou P, Liu K, Xue Y, Hu M, Ling W, Huang Y, Du L, Zheng C, Wang X, Zheng F, Zhang T, Wang Y, Shao C, Melino G, Shi Y*, Wang Y*. MHC class Ib-restricted CD8+ T cells possess strong tumoricidal activities. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2304689120.
7. Wang Y, Xu M, Sun J, Li X, Shi H, Wang X, Liu B, Zhang T, Jiang X, Lin L, Li, Q, Huang Y, Liang Y, Hu M, Zheng F, Zhang F, Sun J, Shi Y*, Wang Y*. Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer. Nat Metab. 2023 Aug;5(8):1408-1422.
8. Fang J, Hou P, Liu S, Zuo M, Liu Z, Chen W, Han Y, Li Y, Wang T, Feng C, Li P, Shao C*, Shi Y*. NAD+salvage governs the immunosuppressive capacity of mesenchymal stem cells. Cell Mol Immunol. 2023 Oct;20(10):1171-1185.
9. Wang Y, Fang J, Liu B, Shao S, Shi Y*. Reciprocal Regulation of Mesenchymal Stem Cells and Immune Responses. Cell Stem Cell. 2022 Nov 3;29(11):1515-1530.
10. Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J, Hua D, Shao C*, Shi Y*. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduct Target Ther. 2022 Mar 21;7(1):92.
11. Zheng Z, Li YN, Jia S, Zhu M, Cao L, Tao M, Jiang J, Zhan S, Chen Y, Gao PJ, Hu W, Wang Y*, Shao C*, Shi Y*. Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3. Nat Commun. 2021 Oct 27;12(1):6202.
12. Wang X, Lin L, Lan B, Wang Y, Du L, Chen X, Li Q, Liu K, Hu M, Xue Y, Roberts AI, Shao C, Melino G, Shi Y*, Wang Y*. IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages. Sci Adv. 2020 Nov 25;6(48):eabb7389.
13. Liu K, Lin L, Li Q, Xue Y, Zheng F, Wang G, Zheng C, Du L, Hu M, Shao C, Kong X, Melino G, Shi Y*, Wang Y*.Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2462-2472.
14. Fibbe WE*, Shi Y*. FOXO3, a Molecular Search for the Fountain of Youth. Cell Stem Cell. 2019 Mar 7;24(3):351-352.
15. Jiang Y#, Li C#, Wu Q#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F*, Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun. 2019 Jul 3;10(1):2935.
16. Du L, Lin L, Li Q, Liu K, Huang Y, Wang X, Cao K, Chen X, Cao W, Li F, Shao C, Wang Y*, Shi Y*. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties. Cell Metab. 2019 Jun 4;29(6):1363-1375.e8.
17. Yi S, Zhai J, Niu R, Zhu G, Wang M, Liu J, Huang H, Wang Y, Jing X, Kang L, Song W, Shi Y, Tang H*. Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge. Nat Commun. 2018 Sep 24;9(1):3879.
18. Shi Y*, Wang Y, Li Q, Liu K, Hou J, Shao C, Wang Y*. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol. 2018 Aug;14(8):493-507.
19. Yao Y, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, Qian Y*. Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nat Commun. 2017 May 24;8:15402.
20. Shi Y, Du L, Lin L, Wang Y*. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov. 2017 Jan;16(1):35-52.
21. Zheng C, Yang Q, Xua C, Shou P, Cao J, Jiang M, Chen Q, Cao G, Han Y, Li F, Cao W, Zhang L, Zhang L, Shi Y*, Wang Y*. CD11b Regulates Obesity-Induced Insulin Resistance via Limiting Alternative Activation and Proliferation of Adipose Tissue Macrophages. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7239-48.
22. Shi Y, Cao J, Wang Y*. Rethinking regeneration: empowerment of stem cells by inflammation. Cell Death & Differentiation.2015 Dec;22(12):1891-2.
23. Wang Y, Chen X, Cao W, Shi Y*. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014 Nov;15(11):1009-16.
24. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y*. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 2014 Jan 16;40(1):140-52.
25. Yu B, He Z, You P, Han Q, Xiang D, Chen F, Wang M, Liu C, Lin X, Borjigin U, Zi X, Li J, Zhu H, Li W, Han C, Wangensteen KJ, Shi Y, Hui L, Wang X*, Hu Y*. Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell. 2013 Sep 5;13(3):328-40.
26. Phinney DG*, Galipeau J, Krampera M, Martin I, Shi Y, Sensebe L. MSCs: science and trials. Nat Med. 2013 Jul;19(7):812.
27. Sensebé L*, Tarte K, Galipeau J, Krampera M, Martin I, Phinney DG, Shi Y. Limited Acquisition of Chromosomal Aberrations in Human Adult Mesenchymal Stromal Cells. Cell Stem Cell. 2012 Jan 6;10(1):9-10;
28. Shi Y*, Wei L, Wang Y, Ren G. Stem Cells Deployed for Bone Repair Hijacked by T Cells. Cell Stem Cell. 2012 Jan 6;10(1):6-8.
29. Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B, Wen T, Han Y, Rabson AB, Tischfield JA, Shao C, Shi Y*. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell. 2012 Dec 7;11(6):812-24.
30. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N*, Qian Y*. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med. 2012 Jul;18(7):1077-86.
31. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y*. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol. 2011 Oct 12;12(12):1151-8.
32. Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ*. Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease. Immunity. 2011 Aug 26;35(2):273-84.
33. Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, Zhao RC, Shi Y*. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008 Feb 7;2(2):141-50.
34. Wang K, Desai B, Shi Y and Denhardt DT*. Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy through modulating corticosteroid production. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14777-82.
35. Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao RC, Shi Y*. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Res. 2007 Mar;17(3):240-8.
36. Das J, Eynott P, Van Kaer L, Shi Y* , Das G. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nat Med. 2006 Dec;12(12):1345-6.
37. Devadas S, Das J, Liu C, Zhang L, Roberts AI, Pan Z, Moore PA, Das G, Shi Y*. Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells. Immunity. 2006 Aug;25(2):237-47.
38. Yin D, Mufson RA, Wang R, Shi Y*. Fas-mediated cell death promoted by opioids. Nature. 1999 Jan 21;397(6716):218.
39. Shi Y, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP, Green DR*. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science. 1992 Jul 10;257(5067):212-4.
40. Shi YF, Sahai BM, Green DR*. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature. 1989 Jun 22;339(6226):625-6.